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Invitrogen
NBS1 Monoclonal Antibody (1C3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-23263
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C3
Immunogen
The complete coding region of the human p95/NBS1 expressed in E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, MCF7, HeLa, Raji.
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AT V1; AT V2; cell cycle regulatory protein p95; FLJ10155; MGC87362; mutated in Nijmegen Breakage syndrome; Nijmegen breakage syndrome 1 (nibrin); nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; p95 protein of the MRE11/RAD50 complex; p95-NBS1; putative DNA repair protein; unnamed protein product
Gene Aliases: AT-V1; AT-V2; ATV; hNbs1; NBS; NBS1; P95
UniProt ID: (Human) O60934, (Mouse) Q9R207
Entrez Gene ID: (Human) 4683, (Mouse) 27354
DNA damage checkpoint
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
in utero embryonic development
blastocyst growth
DNA repair
double-strand break repair
immune response
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
cell proliferation
positive regulation of cell proliferation
protection from non-homologous end joining at telomere
telomeric 3' overhang formation
positive regulation of telomere maintenance
reciprocal DNA recombination
telomere maintenance in response to DNA damage
mitotic G2/M transition checkpoint
isotype switching
negative regulation of neuron differentiation
negative regulation of viral entry into host cell
regulation of fibroblast proliferation
neuromuscular process controlling balance
R-loop processing
t-circle formation
telomere maintenance via telomere trimming
intrinsic apoptotic signaling pathway
double-strand break repair via alternative nonhomologous end joining
DNA strand resection involved in replication fork processing
negative regulation of telomere capping
protein localization to site of double-strand break
positive regulation of double-strand break repair
regulation of DNA-dependent DNA replication initiation
DNA damage response, signal transduction by p53 class mediator
regulation of cell cycle
protein K63-linked ubiquitination
positive regulation of double-strand break repair via homologous recombination
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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