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Invitrogen
XPC Monoclonal Antibody (3.26)
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FIGURE: 1 / 7
XPC Antibody (MA1-23328) in ICC/IF
Immunofluorescence analysis of XPC was performed using 70% confluent log phase MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with XPC Monoclonal Antibody (3.26) (Product # MA1-23328) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then with Goat anti-Mouse IgG (H+L), Superclonal™ Recombinant Secondary Antibody, Alexa Fluor 488 conjugate (Product # A28175) at a d... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-23328
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3.26
Immunogen
Recombinant XPC purified from E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.15 mg/mL
Amount
115 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa whole cell extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mutant xeroderma pigmentosum group C; NER; nucleotide excision repair protein; p125; unnamed protein product; xeroderma pigmentosum group C; xeroderma pigmentosum group C-complementing protein homolog; xeroderma pigmentosum, complementation group C
Gene Aliases: p125; RAD4; XP3; XPCC
UniProt ID: (Human) Q01831, (Mouse) P51612
Entrez Gene ID: (Human) 7508, (Mouse) 22591
DNA repair
nucleotide-excision repair
mismatch repair
regulation of mitotic cell cycle
response to xenobiotic stimulus
response to auditory stimulus
positive regulation of transcription, DNA-templated
UV-damage excision repair
regulation of cell cycle phase transition
regulation of mitotic cell cycle phase transition
pyrimidine dimer repair by nucleotide-excision repair
cellular response to DNA damage stimulus
response to UV-B
intra-S DNA damage checkpoint
negative regulation of gluconeogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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