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Invitrogen
MBP Monoclonal Antibody (22)
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FIGURE: 1 / 6
MBP Antibody (MA1-25034) in ICC/IF
Immunofluorescence analysis of MBP was performed using 70% confluent log phase RSC96 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with MBP Monoclonal Antibody (22) (Product # MA1-25034, 1:100) in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus 488 (Product # A32766, 1:2,000),... View More
Product Details
MA1-25034
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Zebrafish
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
22
Immunogen
Human myelin basic protein.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 17.3K myelin basic protein; golli mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer; unnamed protein product
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi
UniProt ID: (Human) P02686, (Rat) Q505J1, (Mouse) P04370
Entrez Gene ID: (Human) 4155, (Rat) 24547, (Mouse) 17196
MAPK cascade
immune response
chemical synaptic transmission
central nervous system development
sensory perception of sound
axon ensheathment
response to toxic substance
substantia nigra development
positive regulation of interleukin-6 production
negative regulation of heterotypic cell-cell adhesion
maintenance of blood-brain barrier
myelination
membrane organization
positive regulation of metalloendopeptidase activity
positive regulation of chemokine (C-X-C motif) ligand 2 production
aging
response to progesterone
response to tumor necrosis factor
response to mercury ion
negative regulation of axonogenesis
response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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