Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Greener Products
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Molecular Testing
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Custom Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • How to Order
    • Instrument Support
    • Learning Centers
    • Register for an Account
    • Technical Support Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Biotech
    • Biopharma
    • CDMO
    • Lab Diagnostics
    • Industrial and Applied Sciences
  • New Products
  • Promotions
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Order Status
          • Quick Order
          • Promos
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Aspire Member Program
            • Connect: Lab, Data, Apps
            • Custom Products & Projects
            • Services Central
          • Primary Antibodies ›
          • Connexin 43 Antibodies

          Invitrogen

          Connexin 43 Monoclonal Antibody (CXN-6)

          View all (42) Connexin 43 antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Datasheet
          Certificates
          Protocols
          Questions & Answers

          Cite Connexin 43 Monoclonal Antibody (CXN-6)

          {{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

          {{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}
          Connexin 43 Monoclonal Antibody (CXN-6)

          Product Details

          MA1-25097

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:8,000-1:16,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200-1:500
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:200-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:200-1:500
          -

          ELISA (ELISA)

          Assay-dependent
          -
          Product Specifications

          Species Reactivity

          Bovine, Hamster, Human, Mouse, Rat

          Host/Isotype

          Mouse / IgM

          Class

          Monoclonal

          Type

          Antibody

          Clone

          CXN-6

          Immunogen

          Synthetic connexin-43 peptide (362-381).
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.9 mg/mL

          Amount

          45 µg

          Storage buffer

          Ascites

          Contains

          15mM sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_779902

          Product Specific Information

          Recommended positive controls: mouse whole brain.

          Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

          Target Information

          Connexin 43 (Cx43), encoded by the GJA1 gene, is a widely expressed gap junction protein that plays an important role in direct cell-to-cell communication. Six Cx43 proteins assemble to form a connexon, or hemichannel, which can pair with a connexon on a neighboring cell to create a gap junction channel. These channels allow ions, metabolites, and small signaling molecules to pass between adjacent cells, helping coordinate processes such as electrical conduction, tissue development, wound healing, and cellular homeostasis. Cx43 is especially abundant in tissues such as the heart, brain, bone, and skin, and changes in its expression, localization, or function have been associated with cardiovascular disease, neurological disorders, impaired tissue repair, and cancer. Because of its broad role in intercellular signaling and disease biology, Cx43 is an important target for studying gap junction function and developing potential therapeutic strategies.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: alpha 1 connexin; connexin 43; connexin k1; connexin-43; Cx-43; cx43; CXA1; DFNB38; gap junction 43 kDa heart protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; GJA1; Npm1; ODD; ODOD; SDTY3; Syndactyly type III; unnamed protein product; vascular smooth muscle connexin-43; vascular smooth muscle connexin43; VEGF

          View more View less

          Gene Aliases: AVSD3; CMDR; Cnx43; connexin43; CX43; Cx43alpha1; Cxnk1; EKVP; EKVP3; Gja-1; GJAL; HLHS1; HSS; Npm1; ODDD; PPKCA

          View more View less

          UniProt ID: (Human) P17302, (Bovine) P18246, (Mouse) P23242, (Rat) P08050

          View more View less

          Entrez Gene ID: (Human) 2697, (Bovine) 281193, (Mouse) 14609, (Rat) 24392, (Chinese hamster) 100689077

          View more View less

          Function(s)
          receptor binding gap junction channel activity protein binding beta-catenin binding ion transmembrane transporter activity efflux transmembrane transporter activity tubulin binding transmembrane transporter activity glutathione transmembrane transporter activity alpha-tubulin binding beta-tubulin binding gap junction hemi-channel activity gap junction channel activity involved in cardiac conduction electrical coupling scaffold protein binding gap junction channel activity involved in cell communication by electrical coupling protein tyrosine kinase binding SH3 domain binding PDZ domain binding channel activity protein domain specific binding connexin binding disordered domain specific binding gap junction
          Process(es)
          establishment of mitotic spindle orientation cardiac conduction system development cell communication signal transduction cell-cell signaling spermatogenesis heart development protein localization male gonad development positive regulation of gene expression cell communication by electrical coupling glutamate secretion gap junction assembly negative regulation of cell growth negative regulation of gonadotropin secretion ion transmembrane transport glutathione transmembrane transport maintenance of blood-brain barrier T cell proliferation T cell activation xenobiotic transport positive regulation of I-kappaB kinase/NF-kappaB signaling cell-cell junction organization bone remodeling transmembrane transport bone development cellular response to pH atrial cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction microtubule-based transport positive regulation of cold-induced thermogenesis export across plasma membrane negative regulation of trophoblast cell migration regulation of blood circulation cellular response to beta-amyloid positive regulation of vascular smooth muscle cell proliferation positive regulation of morphogenesis of an epithelium positive regulation of mesodermal cell differentiation positive regulation of stem cell proliferation in utero embryonic development neuron migration heart looping epithelial cell maturation adult heart development regulation of heart contraction negative regulation of cell proliferation response to pH ATP transport cellular protein localization embryonic heart tube development regulation of apoptotic process skeletal muscle tissue regeneration positive regulation of protein catabolic process positive regulation of striated muscle tissue development blood vessel morphogenesis neuron projection morphogenesis protein oligomerization osteoblast differentiation negative regulation of endothelial cell proliferation lens development in camera-type eye chronic inflammatory response positive regulation of glomerular filtration atrial ventricular junction remodeling epicardial cell to mesenchymal cell transition positive regulation of cytosolic calcium ion concentration vascular transport negative regulation of gene expression cell communication by chemical coupling regulation of cell communication by electrical coupling positive regulation of cell communication by chemical coupling regulation of bone mineralization positive regulation of insulin secretion maintenance of protein localization in endoplasmic reticulum vasodilation embryonic digit morphogenesis positive regulation of meiotic nuclear division positive regulation of vasoconstriction regulation of bone remodeling regulation of body fluid levels regulation of calcium ion transport negative regulation of cardiac muscle cell proliferation milk ejection regulation of ventricular cardiac muscle cell membrane repolarization regulation of blood vessel remodeling regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction establishment of epithelial cell polarity regulation of actin filament organization positive regulation of establishment of Sertoli cell barrier negative regulation of DNA biosynthetic process regulation of bicellular tight junction assembly positive regulation of behavioral fear response response to ischemia endothelium development response to wounding response to glucose response to estradiol response to lipopolysaccharide response to retinoic acid response to fluid shear stress cellular response to platelet-derived growth factor stimulus response to peptide hormone decidualization cellular response to mechanical stimulus cellular response to parathyroid hormone stimulus positive regulation of smooth muscle cell chemotaxis epididymis development
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Consumer Health Data Privacy Policy Consumer Health Data Privacy Policy
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Notice
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          United States flag icon
          United States

          Your items have has been added!


          Host server : magellan-search-green-5db85fbf84-lw26s:80/100.66.78.224:80.
          git-commit: 64d6f4084a597c0a860dbc264f43a6f389f0d7ac
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.60.1-2026-secondary-format-patch