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Invitrogen
Factor VIII Monoclonal Antibody (012)
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Product Details
MA1-27389
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
012
Immunogen
Purified, native human Factor VIII A2 domain.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
MA1-27389 detects Factor VIII A2 domain from human samples.
MA1-27389 has been successfully used in Western blot procedures. This antibody binds both human factor VIII and human factor VIIIa in solid-phase ELISA. It binds human factor VIII A2 domain in immunoblotting techniques.
The MA1-27389 immunogen is purified, native human Factor VIII A2 domain.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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