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Invitrogen
Cytokeratin Pan Type II Monoclonal Antibody (AE3)
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Product Details
MA1-35368
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Mouse,
Rabbit,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
AE3
Immunogen
Human epidermal keratin
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
250 µg
Purification
purified
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
Target Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; 70 kd type II; alpha keratin; CK-1; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-7; CK-72; CK-8; cytokeratin 1; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; cytokeratin endo A; cytokeratin otokeratin; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; cytokeratin-1; cytokeratin-2e; cytokeratin-2P; cytokeratin-3; cytokeratin-4; cytokeratin-5; cytokeratin-6A; cytokeratin-7; cytokeratin-72; cytokeratin-8; cytokeratin-A; cytoskeletal 57 kDa keratin; cytoskeletal protein; ear specific cytokeratin; EndoA cytokeratin (5' end put.); putative; EndoA' cytokeratin (5' end put.); putative; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epithelial keratin-2e; hair alpha protein; intermediate filament; intermediate filament protein; K7; K1; K2e; K2P; K3 keratin; K5; K6-alpha; K7; K72; K76; K8; KERA; keratin 1, type II; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6, inner root sheath, 2; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 72, pseudogene; keratin 72, type II; keratin 76, type II; keratin 8; keratin 8, type II; keratin 86; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 35; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin IV; keratin K3; keratin K5; keratin protein K6irs; keratin type II; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; keratin, type II cytoskeletal 60 kDa, component III; keratin, type II cytoskeletal 6A; keratin-2 epidermis; keratin-2e; keratin-6-alpha; KRT5; MGC116967; MGC116968; mK6-alpha; otokeratin; pan keratin; Sak57; sarcolectin; tuftelin interacting protein 8; type II alpha-keratin IIA; type II alpha-keratin IIC; type II cytokeratin A (no.8); type II cytoskeletal cochleal; type II inner root sheath-specific keratin-K6irs2; type II intermediate filament protein; type II keratin Kb2; type II keratin Kb35; type II keratin Kb9; type II keratin subunit protein; type II mesothelial keratin K7; type-II keratin Kb1; type-II keratin Kb2; Type-II keratin Kb3; type-II keratin Kb35; type-II keratin Kb4; type-II keratin Kb5; type-II keratin Kb6; type-II keratin Kb7; type-II keratin Kb8; type-II keratin Kb9; type-II keratin-35; unnamed protein product
Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; AEI2; CARD2; CK 2e; CK-2e; CK-3; CK-4; CK-5; CK-6A; CK-6C; CK-6E; CK-72; CK-8; CK1; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK4; CYK8; CYKER; D15Wsu77e; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EHK; EHK1; EndoA; EPPK; HUMCYT2A; K1; K2C7; K2C8; K2e; K3; K4; K5; K6[a]; K6A; K6C; K6D; K6irs; K6IRS2; K7; K72; K76; K8; Kb1; Kb2; Kb35; Kb4; Kb9; keratin; KERIA; KERIB; KO; Krt-2.1; Krt-2.4; Krt-2.8; KRT1A; Krt2-1; Krt2-17; Krt2-2; Krt2-35; Krt2-4; Krt2-5; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; KRT2A; KRT2B; KRT2E; KRT2P; KRT5A; KRT6; KRT6C; KRT6D; KRT6IRS2; Krt72-ps; Krt86; KRTE; MECD2; mK6[a]; MK6a; NEPPK; PC3; Sak57; SCL; Tfip8; TROMA-1; WSN1
UniProt ID: (Human) P04264, (Human) P35908, (Rabbit) Q29426, (Human) P12035, (Human) P19013, (Bovine) Q5XQN5, (Human) P13647, (Human) P02538, (Human) P08729, (Bovine) Q29S21, (Chicken) O93532, (Bovine) Q148H8, (Human) Q14CN4, (Human) Q01546, (Bovine) P05786, (Human) P05787, (Rat) Q6IMF3, (Mouse) P04104, (Rat) Q6IG02, (Mouse) Q3TTY5, (Rat) Q6IG00, (Mouse) P07744, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Rat) Q6IG12, (Rat) Q6IG04, (Mouse) Q6IME9, (Mouse) Q3UV17, (Rat) Q10758, (Mouse) P11679
Entrez Gene ID: (Rabbit) 100353415, (Human) 3848, (Rabbit) 100353162, (Human) 3849, (Bovine) 407188, (Rabbit) 100353668, (Human) 3850, (Human) 3851, (Rabbit) 100348388, (Bovine) 527819, (Chicken) 407779, (Rabbit) 100352658, (Bovine) 281268, (Human) 3852, (Bovine) 614456, (Human) 3853, (Chicken) 408041, (Human) 3855, (Rabbit) 100345579, (Bovine) 535697, (Chicken) 395772, (Bovine) 531057, (Human) 140807, (Human) 51350, (Bovine) 407189, (Rabbit) 100348891, (Bovine) 281269, (Chicken) 426896, (Human) 3856, (Rat) 300250, (Mouse) 16678, (Rat) 406228, (Mouse) 16681, (Rat) 315323, (Mouse) 16682, (Rat) 369017, (Mouse) 110308, (Rat) 120093743, (Mouse) 16687, (Mouse) 110310, (Rat) 300242, (Rat) 406227, (Mouse) 105866, (Rat) 407757, (Mouse) 77055, (Rat) 25626, (Mouse) 16691
keratinization
intermediate filament organization
biological_process
keratinocyte development
epidermis development
keratinocyte activation
keratinocyte proliferation
positive regulation of epidermis development
keratinocyte migration
cornification
tumor necrosis factor-mediated signaling pathway
sarcomere organization
response to hydrostatic pressure
response to other organism
epithelium development
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
negative regulation of hepatocyte apoptotic process
cytoskeleton organization
epithelial cell differentiation
negative regulation of epithelial cell proliferation
response to mechanical stimulus
regulation of cell migration
regulation of protein localization
intermediate filament polymerization
complement activation, lectin pathway
negative regulation of inflammatory response
protein heterotetramerization
establishment of skin barrier
morphogenesis of an epithelium
positive regulation of cell proliferation
cell differentiation
negative regulation of cell migration
killing of cells of other organism
wound healing
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of entry of bacterium into host cell
Wnt signaling pathway
pigmentation
sebaceous gland development
response to oxidative stress
fibrinolysis
regulation of angiogenesis
intermediate filament cytoskeleton organization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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