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Invitrogen
MRP2 Monoclonal Antibody (M2I-4)
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Product Details
MA1-35603
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
M2I-4
Immunogen
cMOAB/MRP2 amino acids 215-310
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
250 µg/mL
Amount
250 µg
Storage buffer
tissue culture supernatant with 0.7% BSA
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
M2I-4 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2I-4 was raised against a bacterial fusion protein of cMOAB/MRP2, containing amino acids 215-310 of the protein. M2I-4 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.
Target Information
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; Human MRP2; KIAA1010; multidrug resistance-associated protein 2
Gene Aliases: ABC30; CMOAT; cMRP; DJS; MRP2
UniProt ID: (Human) Q92887
Entrez Gene ID: (Human) 1244
protein binding
ATP binding
xenobiotic-transporting ATPase activity
bilirubin transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
ATPase activity
toxin transporter activity
transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
ABC-type transporter activity
xenobiotic metabolic process
drug transmembrane transport
lipid transport
negative regulation of gene expression
bile acid and bile salt transport
bilirubin transport
heme catabolic process
drug export
carboxylic acid transport
transmembrane transport
transepithelial transport
leukotriene transport
transport across blood-brain barrier
drug transport across blood-brain barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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