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Invitrogen
MRP5 Monoclonal Antibody (M5II-54)
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FIGURE: 1 / 2
MRP5 Antibody (MA1-35684) in Flow
Oncology reports 2024 -
Figure 2. MRP5 expression at the mRNA level in (A) MIA Paca-2 and (B) PANC-1 clones transduced with scrambled control and multidrug resistance protein 5-short-hairpin RNA. Relative MRP5 mRNA expression was detected by reverse transcription-quantitative PCR. MRP5 mRNA expression was normalised to the reference gene GAPDH and relative quantitation of gene expression was calculated using the comparative thresh... View More
Product Details
MA1-35684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
M5II-54
Immunogen
MRP5 aa 722-910
Conjugate
Form
Liquid
Concentration
250 µg/mL
Amount
250 µg
Storage buffer
tissue culture supernatant with 0.7% BSA
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
M5II-54 reacts with an internal epitope of MRP5, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP. M5II-54 was raised against a bacterial fusion protein of MRP5, containing amino acids 722-910 of the protein. M5I-1 does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC 33; ABC transporter protein; ABCC 5; ABCC5_v2; ATP-binding cassette, sub-family C (CFTR/MRP), member 5, variant 2; ABCC5_v3; ATP-binding cassette, sub-family C (CFTR/MRP), member 5, variant 3; ABCC5_v4; ATP-binding cassette, sub-family C (CFTR/MRP), member 5, variant 4; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; MOAT C; MOAT-C; MRP 5; MRP/cMOAT-related ABC transporter; MRP5; Multi-specific organic anion transporter C; Multidrug resistance-associated protein 5; pABC 11; pABC11; pABC11; MOAT-C; MRP5; SMRP; transporter
Gene Aliases: ABC33; ABCC5; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
UniProt ID: (Human) O15440
Entrez Gene ID: (Human) 10057
nucleotide binding
ATP binding
organic anion transmembrane transporter activity
xenobiotic-transporting ATPase activity
purine nucleotide transmembrane transporter activity
heme transporter activity
efflux transmembrane transporter activity
ATPase activity
macromolecule transmembrane transporter activity
glutathione transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
carbohydrate derivative transmembrane transporter activity
xenobiotic metabolic process
drug transmembrane transport
purine nucleotide transport
hyaluronan biosynthetic process
glutathione transmembrane transport
heme transmembrane transport
xenobiotic transport
transmembrane transport
cAMP transport
cGMP transport
anion transmembrane transport
reduced folate transmembrane transport
export across plasma membrane
transport across blood-brain barrier
drug transmembrane export
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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