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Invitrogen

Galectin 3 Monoclonal Antibody (B2C10)

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View all (90) Galectin 3 antibodies

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Galectin 3 Monoclonal Antibody (B2C10)

Product Details

MA1-40229

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50-1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunohistochemistry (Frozen) (IHC (F))

1:50
-

Flow Cytometry (Flow)

1:50
-

ELISA (ELISA)

1:50
-

Neutralization (Neu)

-
View 1 publication 1 publication

Functional Assay (Functional)

1:50
-

Inhibition Assays (Inhibition)

-
View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

B2C10

Immunogen

First 45 residues of human Galectin-3 (aa 1-45).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS with 0.1% BSA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2109171

Product Specific Information

MA1-40229 detects Galectin-3 from human and mouse samples. This antibody does not cross react with Galedin-3C and is cross reactive with mouse galectin-3.

MA1-40229 has been successfully used in flow cytometry, immunohistochemistry (frozen), immunohistochemistry (paraffin), functional assays, ELISA and Western blot applications.

The MA1-40229 immunogen is the first 45 residues of human Galectin-3.

Endotoxin <24 EU/mg.

Positive control: Huvec cells

Target Information

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 34 kDa beta-galactoside-binding lectin (L-34); 35 kDa lectin; advanced glycation end-product receptor 3; carbohydrate binding protein 35; carbohydrate-binding protein 35; CBP 35; CBP-30; epididymis secretory sperm binding protein; epithelial-specific lectin; gal-3; galactose-specific lectin 3; Galectin3; IgE-binding protein; L-29; L-34 galactoside-binding lectin; laminin-binding protein; lectin L-29; lectin, galactoside-binding, soluble, 3; LGALS3; MAC-2 antigen; unnamed protein product

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Gene Aliases: CBP35; GAL3; GALBP; GALIG; GBP; L-34; L31; LGALS2; Mac-2; MAC2

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UniProt ID: (Human) P17931

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Entrez Gene ID: (Human) 3958, (Mouse) 16854

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Function(s)
RNA binding protein phosphatase inhibitor activity protein binding IgE binding protein phosphatase binding carbohydrate binding chemoattractant activity laminin binding disaccharide binding oligosaccharide binding molecular condensate scaffold activity receptor ligand inhibitor activity receptor inhibitor activity Fc-gamma receptor I complex binding monosaccharide binding advanced glycation end-product receptor activity
Process(es)
monocyte chemotaxis neutrophil chemotaxis epithelial cell differentiation positive regulation of protein complex assembly killing of cells of other organism regulation of T cell proliferation negative regulation of endocytosis eosinophil chemotaxis macrophage chemotaxis negative regulation of T cell receptor signaling pathway positive chemotaxis negative regulation of NK T cell activation antimicrobial humoral immune response mediated by antimicrobial peptide regulation of T cell apoptotic process mononuclear cell migration positive regulation of mononuclear cell migration positive regulation of calcium ion import regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to plasma membrane negative regulation of immunological synapse formation negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of dendritic cell differentiation negative regulation of extrinsic apoptotic signaling pathway skeletal system development positive regulation of cell proliferation positive regulation of serotonin secretion extracellular matrix organization negative regulation of apoptotic process maintenance of protein location positive regulation of angiogenesis NK T cell activation negative regulation of cell proliferation in bone marrow
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