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Invitrogen
HIV1 Rev Group M Monoclonal Antibody (10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-71514
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10
Immunogen
Recombinant Rev protein of HIV-1 BRV purified from E. coli
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with HIV-1 Rev subtype B. It has been mapped to amino acids 34-40 (TRGARRN - subtype B a.a. consensus).
This clone may also be referred to as 10 (03-002).
Target Information
The HIV-1 Rev (regulator of expression of virion) protein is essential for the replication of HIV-1, especially in group M, which is the predominant and most widespread group of HIV-1 responsible for the global HIV epidemic. The Rev protein is encoded by the rev gene and plays a critical role in the nuclear export of unspliced and singly spliced viral mRNAs, which is crucial for the expression of structural proteins and the production of new virions. Structurally, Rev consists of an arginine-rich motif that allows it to bind to the Rev Response Element (RRE) within the viral RNA. This interaction facilitates the recruitment of the nuclear export receptor CRM1, which, along with other cofactors, translocates the RNA out of the nucleus. Functional disruption of Rev or its interaction with RRE significantly impedes HIV-1 replication, making these interactions potential targets for antiretroviral therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIV group M; HIV-1 Rev
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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