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Invitrogen

Protein APC Monoclonal Antibody (KT45)

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Protein APC Monoclonal Antibody (KT45)

Product Details

MA1-72530

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

KT45

Immunogen

Adenomatous polyposis coli protein fused to GST (aa 2170-2394)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_923265

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenomatosis polyposis coli; FAP; FPC; multiple intestinal neoplasia; unnamed protein product

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Gene Aliases: CC1; mAPC; Min

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Entrez Gene ID: (Mouse) 11789

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Function(s)
protease binding protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding ubiquitin protein ligase binding macromolecular complex binding gamma-catenin binding microtubule plus-end binding dynein complex binding
Process(es)
mitotic cytokinesis cell fate specification kidney development hair follicle development cellular response to DNA damage stimulus negative regulation of microtubule depolymerization metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint establishment or maintenance of cell polarity pattern specification process nervous system development axonogenesis negative regulation of cell proliferation insulin receptor signaling pathway axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation Wnt signaling pathway cell migration stem cell population maintenance negative regulation of Wnt signaling pathway regulation of cell migration positive regulation of cell migration regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAPK cascade skin development regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation chromosome organization regulation of cell cycle positive regulation of cell division regulation of attachment of spindle microtubules to kinetochore retina development in camera-type eye negative regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development protein-containing complex assembly nitrogen cycle metabolic process negative regulation of canonical Wnt signaling pathway positive regulation of cold-induced thermogenesis negative regulation of cell cycle G1/S phase transition positive regulation of protein localization to centrosome negative regulation of G1/S transition of mitotic cell cycle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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