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Invitrogen

Caveolin 1 Monoclonal Antibody (7C8)

Advanced Verification
10 Published Figures
11 References
View all (46) Caveolin 1 antibodies

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Caveolin 1 Monoclonal Antibody (7C8)

Product Details

MA3-600

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20
-

Immunocytochemistry (ICC/IF)

1:125
View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent
-

Immunoprecipitation (IP)

1-3 µL
-
Product Specifications

Species Reactivity

Hamster, Human, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7C8

Immunogen

Intercellular membrane protein-containing vesicles (containing GLUT4) from rat.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_779568

Product Specific Information

MA3-600 detects caveolin from human, rat and hamster samples.

MA3-600 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a 19-21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65-70 kDa.

The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.

Target Information

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: caveolae; caveolin 1, caveolae protein; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; caveolin-like; cell growth-inhibiting protein 32; GIG32; HGNC:1527; OTTHUMP00000196475; unnamed protein product

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Gene Aliases: BSCL3; Cav; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21

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UniProt ID: (Human) Q03135

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Entrez Gene ID: (Human) 857, (Rat) 25404, (Chinese hamster) 100753021

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Function(s)
receptor binding patched binding protein binding oxysterol binding cholesterol binding peptidase activator activity enzyme binding protein kinase binding protein tyrosine kinase inhibitor activity protein binding, bridging small GTPase binding nitric-oxide synthase inhibitor activity identical protein binding ion channel binding macromolecular complex binding protein heterodimerization activity nitric-oxide synthase binding ATPase binding binding, bridging inward rectifier potassium channel inhibitor activity protein sequestering activity SNARE binding kinase binding receptor serine/threonine kinase binding scaffold/adaptor protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation triglyceride metabolic process calcium ion transport cellular calcium ion homeostasis regulation of smooth muscle contraction skeletal muscle tissue development protein localization cellular response to starvation response to bacterium positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression positive regulation of cholesterol efflux vesicle organization receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage cell differentiation regulation of blood coagulation cholesterol transport positive regulation of cell migration negative regulation of BMP signaling pathway negative regulation of epithelial cell differentiation mammary gland development T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization maintenance of protein location in cell response to progesterone nitric oxide homeostasis insulin receptor internalization angiotensin-activated signaling pathway cholesterol homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAPK cascade response to estrogen protein localization to plasma membrane raft negative regulation of nitric oxide biosynthetic process positive regulation of vasoconstriction nitric oxide metabolic process negative regulation of JAK-STAT cascade negative regulation of pinocytosis regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization calcium ion homeostasis mammary gland involution canonical Wnt signaling pathway negative regulation of necroptotic process caveola assembly cellular response to misfolded protein cellular response to peptide hormone stimulus cellular response to hyperoxia caveolin-mediated endocytosis regulation of heart rate by cardiac conduction negative regulation of canonical Wnt signaling pathway apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of ventricular cardiac muscle cell action potential positive regulation of cold-induced thermogenesis regulation of ruffle assembly negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction protein localization to basolateral plasma membrane positive regulation of gap junction assembly positive regulation of ERAD pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway angiogenesis positive regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway regulation of the force of heart contraction response to ischemia regulation of the force of heart contraction by chemical signal response to nutrient lactation negative regulation of cell proliferation response to xenobiotic stimulus response to mechanical stimulus positive regulation of signal transduction negative regulation of signal transduction response to gamma radiation negative regulation of muscle cell apoptotic process negative regulation of smooth muscle cell migration protein transport organ regeneration positive regulation of microtubule polymerization cholesterol efflux vasoconstriction negative regulation of tyrosine phosphorylation of STAT protein positive regulation of catalytic activity negative regulation of MAP kinase activity negative regulation of neuron differentiation positive regulation of endocytosis microtubule polymerization negative regulation of smooth muscle cell proliferation negative regulation of nitric-oxide synthase activity response to glucocorticoid regulation of peptidase activity negative regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus basement membrane organization cellular senescence regulation of potassium ion export across plasma membrane negative regulation of vascular smooth muscle cell proliferation negative regulation of calcium ion import across plasma membrane
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