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CRMP5 Monoclonal Antibody (CR-1)
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FIGURE: 1 / 4
CRMP5 Antibody (MA3-701) in ICC/IF
Immunofluorescence analysis of CRMP5 was done on 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with CRMP5 (CR-1) Rat Monoclonal Antibody (Product # MA3-701) at 1:250 dilution in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rat IgG (H+L) Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A-11006) at a diluti... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA3-701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Rat
Published species
Human
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CR-1
Immunogen
CRMP5 protein purified from human brain.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA3-701 detects human, bovine, rat and C-terminal region of CRMP5. This antibody has not been shown to be reactive in mouse samples.
MA3-701 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects an ~ 62 kDa protein corresponding to human CRMP5 from brain extract.
The MA3-701 antigen is a purified protein from human brain. This antibody is specific for the C-terminal region, amino acids 369 - 564. Not reactive with other CRMP isoforms.
Target Information
The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: collapsin response mediator protein-5; CRMP3-associated molecule; dihydropyrimidinase-related protein 5-like; DRP-5; ULIP-6; ULIP6 protein; UNC33-like phosphoprotein 6
Gene Aliases: CRAM; CRMP-5; CRMP5; CV2; RTSC4; Ulip6
UniProt ID: (Human) Q9BPU6, (Rat) Q9JHU0
Entrez Gene ID: (Human) 56896, (Bovine) 100126171, (Rat) 65208
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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