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Invitrogen
HCN3 Monoclonal Antibody (TLL6C5)
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FIGURE: 1 / 3
HCN3 Antibody (MA3-902) in IHC (P)
Immunohistochemistry was performed on cancer biopsies of deparaffinized Human colon carcinoma tissues. To expose target proteins, heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Following antigen retrieval tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then probed at a dilution of 1:20 with a rat monoclo... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA3-902
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TLL6C5
Immunogen
Synthetic peptide corresponding to residues T(640) L L A R S A R R S A G S P A S P L V P V R A G P L L A R G P W A S T S(675) of rat HCN3.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA3-902 detects HCN3 from human, mouse and rat samples.
MA3-902 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot MA3-902 detects a ~90 KDa band representing HCN3.
The MA3-902 immunogen is a synthetic peptide corresponding to residues T(640) L L A R S A R R S A G S P A S P L V P V R A G P L L A R G P W A S T S(675) of rat HCN3.
MA3-902 (clone TLL6C5) is a rat monoclonal hybridoma, produced by immunizing a rat, isolating the spleen cells, creating the hybridoma and successively injecting these cells into a mouse to produce ascites.
Target Information
HCN3 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. HCN3 has been detected in the brain, but with less expression than other HCN channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hyperpolarization-activated cation channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; MGC131493; potassium channel; unnamed protein product
Gene Aliases: BCNG-4; Bcng4; HAC-3; Hac3; Hcn4
UniProt ID: (Human) Q9P1Z3, (Mouse) O88705, (Rat) Q9JKA8
Entrez Gene ID: (Human) 57657, (Mouse) 15168, (Rat) 114245
regulation of membrane depolarization
ion transport
potassium ion transport
sodium ion transmembrane transport
regulation of membrane potential
transmembrane transport
cellular response to cAMP
potassium ion transmembrane transport
cellular response to dopamine
regulation of heart rate by cardiac conduction
sodium ion import across plasma membrane
regulation of SA node cell action potential
potassium ion import across plasma membrane
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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