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Invitrogen
Transferrin Receptor Monoclonal Antibody (10F11)
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FIGURE: 1 / 10
Transferrin Receptor Antibody (MA5-11441) in IHC (P)
Immunohistochemistry analysis of CD71 showing positive staining in the cytoplasm and membrane of paraffin-treated Human placenta tissue (right) compared with a negative control in the absence of primary antibody (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0) microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-met... View More
Product Details
MA5-11441
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Hamster,
Human,
Rhesus monkey,
Sheep
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
10F11
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-11441 reacts with human and mouse samples in IHC (P), FACS and Western blot applications. This antibody is not suitable for MCF-7 or NIH-3T3 cells in Western blot analysis.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD antigen CD71; CD71; mammary tumor virus receptor 1; p90; T9; TR; transferrin receptor; Transferrin receptor 1; Transferrin receptor protein 1; unnamed protein product
Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) Q1HE24, (Mouse) Q62351
Entrez Gene ID: (Human) 7037, (Mouse) 22042
virus receptor activity
RNA binding
double-stranded RNA binding
transferrin receptor activity
protein binding
protein kinase binding
Hsp70 protein binding
identical protein binding
protein homodimerization activity
macromolecular complex binding
chaperone binding
glycoprotein binding
iron ion transmembrane transporter activity
transferrin transmembrane transporter activity
poly(A) RNA binding
metalloprotease
regulation of cell growth
response to hypoxia
iron ion transport
cellular iron ion homeostasis
endocytosis
receptor-mediated endocytosis
acute-phase response
signal transduction
cell surface receptor signaling pathway
response to nutrient
response to iron ion
response to manganese ion
positive regulation of gene expression
negative regulation of mitochondrial fusion
osteoclast differentiation
positive regulation of B cell proliferation
positive regulation of protein complex assembly
receptor internalization
response to retinoic acid
transferrin transport
intracellular signal transduction
positive regulation of T cell proliferation
regulation of cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of isotype switching
response to copper ion
viral entry into host cell
multicellular organismal iron ion homeostasis
cellular response to xenobiotic stimulus
regulation of postsynaptic membrane neurotransmitter receptor levels
transport across blood-brain barrier
positive regulation of protein localization to nucleus
cellular response to leukemia inhibitory factor
iron ion transmembrane transport
cellular response to drug
positive regulation of bone resorption
protein transmembrane transport
iron ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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