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Invitrogen
Involucrin Monoclonal Antibody (SY5)
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Product Details
MA5-11803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Non-human primate,
Pig,
Rat
Published species
Human,
Mouse,
Protozoa,
Rat,
Sheep
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
SY5
Immunogen
Human keratinocytes' involucrin
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-11803 targets Involucrin in ELISA, IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Human, Non-human primate, Porcine, and Rat samples.
The MA5-11803 immunogen is human keratinocytes' involucrin.
Target Information
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Involucrin; unnamed protein product
Gene Aliases: IVL
UniProt ID: (Human) P07476, (Pig) P18175, (Rat) P48998
Entrez Gene ID: (Human) 3713, (Dog) 102152041, (Pig) 407242, (Rat) 60583
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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