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Invitrogen
Cardiac Troponin T Monoclonal Antibody (13-11)
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FIGURE: 1 / 91
Cardiac Troponin T Antibody (MA5-12960) in ICC/IF
Immunofluorescent analysis of Troponin T Cardiac Isoform (green) in cultured primary cardiomyocytes. Primary cardiomyocytes were isolated and cultured using the Primary Cardiomyocyte Isolation Kit (Product # 88281). Cells were grown in 24-well plates (seeded at 5x10^5 cells/well) or in 35mm glass bottom plates (at a density of 2.5 x 106 cells/well). At day 1 and day 7, cells were fixed with 4% paraformaldeh... View More
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.jpg?time=20240507?time=20240507 "Cardiac Troponin T Antibody (MA5-12960) in ICC/IF")
.jpg?time=20240507?time=20240507 "Cardiac Troponin T Antibody (MA5-12960) in ICC/IF")
.jpg?time=20240507?time=20240507 "Cardiac Troponin T Antibody (MA5-12960) in IHC (P)")
Product Details
MA5-12960
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Dog,
Chicken,
Fish,
Guinea pig,
Human,
Mouse,
Pig,
Rabbit,
Rat
Published species
Dog,
Fish,
Hamster,
Human,
Mouse,
Pig,
Rat,
Xenopus,
Zebrafish
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
13-11
Immunogen
Purified rabbit cardiac troponin T isoform (TnT4R)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-12960 targets Troponin T Cardiac Isoform in IF/ICC, IHC (P), and IM applications and shows reactivity with Avian, Canine, Chicken, Fish, Guinea Pig, Human, mouse, Porcine, Rabbit, and Rat samples.
The MA5-12960 immunogen is purified rabbit cardiac troponin T isoform (TnT4R).
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; Cardiac muscle troponin T; cardiac TnT; cardiac troponin 2; cardiac troponin T; cardiac troponin T form I; cardiac troponin T isoform I; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; cTnT; MGC3889; TnTC; troponin T; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; Troponin T, cardiac muscle isoforms; Troponin T2; troponin T2, cardiac; unnamed protein product
Gene Aliases: CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTC
UniProt ID: (Human) P45379, (Chicken) P02642, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Human) 7139, (Rabbit) 100009428, (Pig) 100622450, (Dog) 403532, (Chicken) 396433, (Guinea pig) 100379561, (Rat) 24837, (Mouse) 21956
regulation of muscle contraction
striated muscle contraction
regulation of heart contraction
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
sarcomere organization
response to calcium ion
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle contraction
heart development
metabolic process
regulation of muscle filament sliding speed
protein heterooligomerization
actin crosslink formation
atrial cardiac muscle tissue morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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