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Invitrogen
CD68 Monoclonal Antibody (KP1)
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FIGURE: 1 / 25
CD68 Antibody (MA5-13324) in ICC/IF
Immunofluorescent analysis of CD68 (green) showing staining in the membrane of MDA-MB-231 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a CD68 monoclonal antibody (Product # MA5-13324) in 3% BSA-PBS at a dilution of 1:50 and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conj... View More
Product Details
MA5-13324
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Human,
Non-human primate,
Rat
Published species
Cynomolgus monkey,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
KP1
Immunogen
Subcellular fraction of human alveolar macrophages
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13324 targets CD68 in IHC (P) and ICC/IF applications and shows reactivity with Feline, Human, Non-human primate, and Rat samples. Does not react with Canine or Chicken.
The MA5-13324 immunogen is subcellular fraction of human alveolar macrophages.
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 110kda transmembrane glycoprotein; CD68; CD68 antigen; Gp110; macrophage antigen CD68; Macrosialin; scavenger receptor class D, member 1; unnamed protein product
Gene Aliases: CD68; GP110; LAMP4; SCARD1
UniProt ID: (Human) P34810
Entrez Gene ID: (Human) 968, (Rat) 287435
inflammatory response to antigenic stimulus
negative regulation of dendritic cell antigen processing and presentation
cellular response to nutrient levels
autocrine signaling
response to ethanol
cellular response to lipopolysaccharide
establishment of protein localization to organelle
cellular response to oxidised low-density lipoprotein particle stimulus
cellular response to organic substance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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