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Invitrogen
Thrombospondin 1 Monoclonal Antibody (A6.1)
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FIGURE: 1 / 51
Thrombospondin 1 Antibody (MA5-13398) in ICC/IF
Immunofluorescent analysis of Thrombospondin (green) showing staining in the secretion of HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a Thrombospondin monoclonal antibody (Product # MA5-13398) in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4 °C in a h... View More
Product Details
MA5-13398
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Human,
Mouse,
Sheep,
Pig,
Rat
Published species
Human,
Mouse,
Rat,
Sheep
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
A6.1
Immunogen
Reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13398 targets Thrombospondin in FACS, ICC/IF, IHC (P), IM, IP, and WB applications and shows reactivity with Bovine, Canine, Equine, Human, mouse, Ovine, Porcine, and Rat samples.
The MA5-13398 immunogen is reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets.
Target Information
Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Glycoprotein G; Thrombospondin; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; unnamed protein product
Gene Aliases: tbsp1; THBS; THBS-1; THBS1; TSP; TSP-1; TSP1
UniProt ID: (Human) P07996, (Bovine) Q28178
Entrez Gene ID: (Horse) 100057478, (Human) 7057, (Dog) 487486, (Bovine) 281530, (Pig) 492313, (Sheep) 101106433, (Rat) 445442, (Mouse) 21825
phosphatidylserine binding
fibronectin binding
protease binding
endopeptidase inhibitor activity
integrin binding
extracellular matrix structural constituent
calcium ion binding
protein binding
heparin binding
fibroblast growth factor binding
low-density lipoprotein particle binding
protein homodimerization activity
laminin binding
proteoglycan binding
transforming growth factor beta binding
extracellular matrix binding
fibrinogen binding
collagen V binding
angiogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
negative regulation of cell-matrix adhesion
sprouting angiogenesis
chronic inflammatory response
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of dendritic cell antigen processing and presentation
positive regulation of immune system process
apoptotic process
inflammatory response
immune response
response to unfolded protein
cell adhesion
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
response to mechanical stimulus
response to glucose
positive regulation of endothelial cell migration
negative regulation of endothelial cell migration
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of nitric oxide mediated signal transduction
negative regulation of cGMP-mediated signaling
negative regulation of plasminogen activation
positive regulation of macrophage chemotaxis
positive regulation of fibroblast migration
regulation of cell-substrate adhesion
cell migration
negative regulation of angiogenesis
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
response to magnesium ion
response to progesterone
negative regulation of interleukin-10 production
negative regulation of interleukin-12 production
negative regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
positive regulation of transforming growth factor beta1 production
response to testosterone
cellular response to heat
response to endoplasmic reticulum stress
nitric oxide-cGMP-mediated signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of phosphorylation
positive regulation of macrophage activation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
engulfment of apoptotic cell
positive regulation of translation
positive regulation of angiogenesis
behavioral response to pain
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
positive regulation of chemotaxis
response to calcium ion
negative regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
positive regulation of transforming growth factor beta production
blood coagulation, fibrin clot formation
negative regulation of cell migration involved in sprouting angiogenesis
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
negative regulation of sprouting angiogenesis
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
negative regulation of endothelial cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway
activation of MAPK activity
outflow tract morphogenesis
endocardial cushion development
growth plate cartilage development
cell cycle arrest
positive regulation of cell-substrate adhesion
peptide cross-linking
positive regulation of blood coagulation
regulation of cGMP metabolic process
response to drug
positive regulation of tumor necrosis factor biosynthetic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to nitric oxide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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