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Invitrogen
Chromogranin A Monoclonal Antibody (SP12)
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Product Details
MA5-14536
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
SP12
Immunogen
Recombinant protein encoding human chromogranin A
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant/TBS, pH 7.5, with 1% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-14536 targets Chromogranin A in WB, and IHC (P) applications and shows reactivity with Human and Rat samples. This antibody does not cross-react with mouse tissues in IHC applications.
The MA5-14536 immunogen is recombinant protein encoding human chromogranin A.
Target Information
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; chromogranin A; chromogranin A precursor; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I; unnamed protein product
Gene Aliases: CGA; CHGA; PHE5; PHES
UniProt ID: (Human) P10645
Entrez Gene ID: (Human) 1113, (Rat) 24258
regulation of the force of heart contraction
organelle organization
positive regulation of cAMP metabolic process
ovulation cycle
negative regulation of vasodilation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of neuron death
mast cell chemotaxis
regulation of blood pressure
killing of cells of other organism
protein localization to secretory granule
negative regulation of catecholamine secretion
defense response to bacterium
mast cell degranulation
innate immune response
mast cell activation
negative regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
positive regulation of cardiac muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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