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Invitrogen
TCF3 Monoclonal Antibody (H.66.7)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-14850
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
H.66.7
Immunogen
Synthetic peptide corresponding to residues surrounding Gln96 of human TCF3
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: class B basic helix-loop-helix protein 21; e12 protein; E2A-HLF fusion transcript protein; helix-loop-helix protein HE47; immunoglobulin transcription factor 1; kappa-E2-binding factor; MGC129647; MGC129648; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor E2A; transcription factor ITF-1; VDR interacting repressor; vitamin D receptor-interacting repressor
Gene Aliases: AGM8; AGM8A; AGM8B; bHLHb21; E2A; E47; ITF1; p75; TCF-3; VDIR
UniProt ID: (Human) P15923
Entrez Gene ID: (Human) 6929
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
mitogen-activated protein kinase kinase kinase binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
vitamin D response element binding
E-box binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
B cell differentiation
positive regulation of B cell proliferation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of G1/S transition of mitotic cell cycle
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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