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Invitrogen

AXIN1 Monoclonal Antibody (T.618.2)

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View all (21) AXIN1 antibodies

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Product Details

MA5-14853

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

T.618.2

Immunogen

Recombinant protein of human Axin1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

140 µg/mL

Amount

14 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10983681

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: axis inhibition protein 1; axis inhibitor 1; contains RGS domain and Daughterless similarity; fused, mouse, homolog of; LA16c-314G4.3; MGC52315; protein Fused; protein phosphatase 1, regulatory subunit 49

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Gene Aliases: AXIN; CMDOH; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49

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UniProt ID: (Human) O15169, (Mouse) O35625

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Entrez Gene ID: (Human) 8312, (Mouse) 12005

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Function(s)
p53 binding protein binding beta-catenin binding enzyme binding protein kinase binding protein domain specific binding protein binding, bridging ubiquitin protein ligase binding signaling adaptor activity identical protein binding protein homodimerization activity protein serine/threonine kinase activator activity SMAD binding binding, bridging armadillo repeat domain binding I-SMAD binding R-SMAD binding protein serine/threonine kinase binding protein binding, bridging involved in substrate recognition for ubiquitination receptor binding
Process(es)
negative regulation of Wnt signaling pathway positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to glucose starvation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process positive regulation of JNK cascade cell development protein-containing complex assembly negative regulation of canonical Wnt signaling pathway negative regulation of TORC1 signaling beta-catenin destruction complex assembly positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein polyubiquitination in utero embryonic development regulation of protein phosphorylation positive regulation of protein phosphorylation nucleocytoplasmic transport sensory perception of sound dorsal/ventral axis specification dorsal/ventral pattern formation negative regulation of gene expression Wnt signaling pathway protein catabolic process positive regulation of transforming growth factor beta receptor signaling pathway cytoplasmic microtubule organization negative regulation of transcription elongation from RNA polymerase II promoter post-anal tail morphogenesis positive regulation of JUN kinase activity epigenetic programming in the zygotic pronuclei negative regulation of fat cell differentiation positive regulation of protein kinase activity axial mesoderm development axial mesoderm formation negative regulation of protein metabolic process canonical Wnt signaling pathway head development regulation of canonical Wnt signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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