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Invitrogen
FosB Monoclonal Antibody (H.234.10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15056
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
H.234.10
Immunogen
Synthetic peptide corresponding to the sequence of human FosB
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
107 µg/mL
Amount
10.7 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other Fos proteins, including c-fos, FRA1 and FRA2.
Target Information
c-FOS is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. It has a critical function in regulating the development of cells destined to form and maintain the skeleton, and is thought to have an important role in signal transduction, cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activator protein 1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FBJ osteosarcoma oncogene B; fos b; FOSB; FosB proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 3; GOS3 is human homolog of mouse FOSB gene; MGC42291; oncogene FOS-B; osteosarcoma oncoprotein B FosB; protein fosB; transcription factor AP-1 subunit FosB; unnamed protein product
Gene Aliases: AP-1; fra-2; G0S3; GOS3; GOSB
UniProt ID: (Human) P53539, (Mouse) P13346, (Rat) D3ZLB7
Entrez Gene ID: (Human) 2354, (Mouse) 14282, (Rat) 100360880
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
response to amphetamine
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
female pregnancy
response to xenobiotic stimulus
response to mechanical stimulus
response to progesterone
cellular response to hormone stimulus
response to nicotine
response to cocaine
response to morphine
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
behavioral response to cocaine
response to corticosterone
response to cAMP
cellular response to calcium ion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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