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Invitrogen

MEK1 Monoclonal Antibody (K.971.4)

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Product Details

MA5-15093

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunoprecipitation (IP)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

K.971.4

Immunogen

Full length MEK1 proteins

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

227 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981449

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with MEK2 and other MAP kinase kinases.

Target Information

MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK2; mitogen activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; MKK (Thr292); MKK (Thr386); MKK2; MP2K1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product

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Gene Aliases: CFC3; MAP2K1; MAPKK1; MEK1; MEKK1; MEL; MKK1; PRKMK1

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UniProt ID: (Human) Q02750, (Mouse) P31938, (Rat) Q01986

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Entrez Gene ID: (Human) 5604, (Mouse) 26395, (Rat) 170851

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity MAP-kinase scaffold activity protein binding ATP binding kinase activity transferase activity protein kinase binding protein kinase activator activity small GTPase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity macromolecular complex binding scaffold protein binding protein serine kinase activity receptor signaling protein tyrosine phosphatase activity protein C-terminus binding transferase activity, transferring phosphorus-containing groups Ras GTPase binding protein N-terminus binding non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade regulation of vascular smooth muscle contraction chemotaxis response to oxidative stress signal transduction heart development negative regulation of cell proliferation positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression Schwann cell development cerebellar cortex formation central nervous system neuron differentiation neuron differentiation keratinocyte differentiation positive regulation of cell migration thyroid gland development melanosome transport regulation of stress-activated MAPK cascade positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion endodermal cell differentiation ERBB2-ERBB3 signaling pathway myelination positive regulation of MAPK cascade type B pancreatic cell proliferation positive regulation of transcription, DNA-templated positive regulation of muscle contraction positive regulation of Ras protein signal transduction vesicle transport along microtubule insulin-like growth factor receptor signaling pathway Golgi inheritance thymus development response to axon injury regulation of axon regeneration neuron projection morphogenesis cell motility positive regulation of axonogenesis response to glucocorticoid Bergmann glial cell differentiation face development lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development triglyceride homeostasis ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of endodermal cell differentiation negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway regulation of early endosome to late endosome transport positive regulation of ATP biosynthetic process activation of MAPK activity regulation of protein phosphorylation protein phosphorylation cell cycle arrest mitotic nuclear division cell proliferation phosphorylation peptidyl-tyrosine dephosphorylation positive regulation of GTPase activity positive regulation of cell differentiation protein heterooligomerization mitophagy in response to mitochondrial depolarization peptidyl-tyrosine phosphorylation intracellular signal transduction
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