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Invitrogen

Phospho-CSF1R (Tyr723) Monoclonal Antibody (F.540.2)

1 Published Figure
2 References
View all (93) CSF1R (CD115) antibodies

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Phospho-CSF1R (Tyr723) Monoclonal Antibody (F.540.2)

Product Details

MA5-15151

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:300
-

Immunoprecipitation (IP)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

F.540.2

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pTyr723 of human M-CSF receptor
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

228 µg/mL

Amount

22.8 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985855

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with related active protein tyrosine kinases.

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: c-fms; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; proto-oncogene c-Fms; proto-oncogene fms; transmembrane protein; unnamed protein product

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Gene Aliases: BANDDOS; C-FMS; CD115; CSF-1R; Csfmr; CSFR; Fim-2; FIM2; FMS; GPSC; HDLS; HDLS1; M-CSF-R; M-CSFR

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UniProt ID: (Human) P07333, (Mouse) P09581

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Entrez Gene ID: (Human) 1436, (Mouse) 12978

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity macrophage colony-stimulating factor receptor activity protein binding ATP binding growth factor binding protein phosphatase binding cytokine binding protein homodimerization activity
Process(es)
positive regulation of protein phosphorylation myeloid leukocyte differentiation response to ischemia response to stress inflammatory response signal transduction transmembrane receptor protein tyrosine kinase signaling pathway axon guidance cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape anatomical structure morphogenesis positive regulation of macrophage chemotaxis cell migration peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway olfactory bulb development forebrain neuron differentiation regulation of cell morphogenesis hemopoiesis monocyte differentiation macrophage differentiation osteoclast differentiation positive regulation of cell migration ruffle organization positive regulation of chemokine production regulation of actin cytoskeleton organization cellular response to macrophage colony-stimulating factor stimulus macrophage colony-stimulating factor signaling pathway positive regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process regulation of MAPK cascade positive regulation by host of viral process innate immune response regulation of bone resorption cell-cell junction maintenance protein autophosphorylation animal organ development positive regulation of protein kinase B signaling mammary gland duct morphogenesis positive regulation of protein tyrosine kinase activity microglial cell proliferation positive regulation of ERK1 and ERK2 cascade cellular response to cytokine stimulus positive regulation of macrophage proliferation regulation of macrophage migration positive regulation of cell motility microglial cell activation neutrophil homeostasis positive regulation of gene expression negative regulation of myotube differentiation microglia development telencephalon development dentate gyrus development positive regulation of bone mineralization negative regulation of epithelial cell differentiation positive regulation of tumor necrosis factor production regulation of mononuclear cell proliferation monocyte homeostasis positive regulation of osteoclast differentiation positive regulation of lymphocyte proliferation positive regulation of astrocyte activation positive regulation of leukocyte proliferation positive regulation of cell cycle G1/S phase transition negative regulation of platelet formation positive regulation of macrophage migration neuron projection extension positive regulation of myoblast proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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