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Invitrogen

VEGF Receptor 2 Monoclonal Antibody (B.309.4)

Advanced Verification
4 Published Figures
17 References
View all (100) FLK1 (VEGF Receptor 2) antibodies

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VEGF Receptor 2 Monoclonal Antibody (B.309.4)

Product Details

MA5-15157

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 8 publications 8 publications

Immunohistochemistry (IHC)

-
View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:4000-1:16000
-

Immunohistochemistry (Frozen) (IHC (F))

1:200-1:800
-

Immunocytochemistry (ICC/IF)

1:200-1:800
View 4 publications 4 publications

Flow Cytometry (Flow)

-
View 1 publication 1 publication

Immunoprecipitation (IP)

1:100
-

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

B.309.4

Immunogen

Recombinant protein containing the carboxy-terminal 150 amino acid residues of human VEGF receptor 2 (aa 1206-1356).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

28 µg/mL

Amount

2.8 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986085

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with other family members.

Target Information

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; unnamed protein product; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2; VEGFR-2; tyrosine kinase

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Gene Aliases: 6130401C07; CD309; Flk-1; FLK1; KDR; Krd-1; Ly73; sVEGFR-2; VEGFR; VEGFR-2; VEGFR2

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UniProt ID: (Human) P35968, (Mouse) P35918

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Entrez Gene ID: (Human) 3791, (Mouse) 16542

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding coreceptor activity kinase activity transferase activity growth factor binding vascular endothelial growth factor binding identical protein binding cadherin binding Hsp90 protein binding transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
angiogenesis ovarian follicle development patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development lymph vessel development positive regulation of mesenchymal cell proliferation epithelial cell maturation endocardium development endothelium development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape mesenchymal cell proliferation positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of macroautophagy cell migration peptidyl-tyrosine phosphorylation hemopoiesis cell differentiation lung development positive regulation of cell migration positive regulation of BMP signaling pathway embryonic hemopoiesis cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway vascular endothelial growth factor signaling pathway negative regulation of apoptotic process surfactant homeostasis regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration cell fate commitment endothelial cell differentiation positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway lung alveolus development post-embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of positive chemotaxis positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling positive regulation of mitochondrial depolarization calcium ion homeostasis epithelial tube morphogenesis blood vessel endothelial cell differentiation vascular wound healing positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway stem cell proliferation positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission positive regulation of nitric oxide-cGMP mediated signal transduction regulation of hematopoietic progenitor cell differentiation regulation of bone development cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of stem cell proliferation positive regulation of endothelial cell chemotaxis positive regulation of vasculogenesis response to hypoxia regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis endochondral bone growth protein phosphorylation positive regulation of cytosolic calcium ion concentration multicellular organism development male gonad development positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of TOR signaling calcium-mediated signaling using intracellular calcium source peptidyl-tyrosine autophosphorylation response to drug regulation of endothelial cell differentiation positive regulation of vasodilation positive regulation of long-term neuronal synaptic plasticity cell maturation neuron projection morphogenesis positive regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase biosynthetic process
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