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Invitrogen

Neurofilaments 70/200 kDa Monoclonal Antibody (2F11)

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Neurofilaments 70/200 kDa Monoclonal Antibody (2F11)

Product Details

MA5-15234

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50-1:500
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-

Immunocytochemistry (ICC/IF)

1:250
View 1 publication 1 publication

Immunoprecipitation (IP)

10 µg/mL
-
Product Specifications

Species Reactivity

Cat, Human, Mouse, Rabbit, Rat

Published species

Avian, Fish, Mouse, Rabbit

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2F11

Immunogen

Neurofilament purified from human brain
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

15mM sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10982518

Product Specific Information

MA5-15234 targets Neurofilament (200kDa and 68kDa) in IF, IHC (P), IP, and WB applications and shows reactivity with Feline, Human, mouse, Rabbit, and Rat samples.

The MA5-15234 immunogen is neurofilament purified from human brain.

Target Information

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 200 kDa neurofilament protein; 68 kDa neurofilament protein; 68kDa neurofilament; heavy neurofilament polypeptide; heavy neurofilament subunit; high molecular weight neurofilament; hSTEp; intermediate filament; light molecular weight neurofilament protein; NEFH/NEFL; NEFL/NEFH; neurofilament 200kDa; neurofilament protein; neurofilament protein, light chain; neurofilament subunit NF-L; neurofilament triplet H protein; neurofilament triplet L protein; neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament-H; NF-H; Nfh; NF200; protein phosphatase 1, regulatory subunit 110; unnamed protein product

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Gene Aliases: CMT1F; CMT2CC; CMT2E; CMTDIG; mKIAA0845; NF-H; NF-L; NF200; NF68; NFH; NFL; PPP1R110

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UniProt ID: (Human) P12036, (Human) P07196, (Mouse) P19246, (Rat) P19527, (Mouse) P08551

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Entrez Gene ID: (Human) 4744, (Rabbit) 100357177, (Human) 4747, (Rabbit) 100353082, (Mouse) 380684, (Rat) 24587, (Rat) 83613, (Mouse) 18039

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Function(s)
structural constituent of cytoskeleton protein binding microtubule binding kinesin binding protein kinase binding protein binding, bridging dynein complex binding structural constituent of postsynaptic intermediate filament cytoskeleton tubulin binding protein domain specific binding identical protein binding phospholipase binding macromolecular complex binding toxic substance binding molecular condensate scaffold activity
Process(es)
microtubule cytoskeleton organization ovarian follicle atresia axonogenesis axon regeneration neurofilament bundle assembly intermediate filament cytoskeleton organization intermediate filament bundle assembly peripheral nervous system neuron axonogenesis neurofilament cytoskeleton organization axon development postsynaptic modulation of chemical synaptic transmission postsynaptic intermediate filament cytoskeleton organization regulation of organelle transport along microtubule response to sodium arsenite cellular response to leukemia inhibitory factor anterograde axonal transport retrograde axonal transport response to toxic substance axonal transport of mitochondrion spinal cord development hippocampus development cerebral cortex development response to peptide hormone intermediate filament polymerization or depolymerization intermediate filament organization protein polymerization response to corticosterone regulation of synapse maturation response to acrylamide cell projection assembly peripheral nervous system axon regeneration regulation of axon diameter locomotion negative regulation of neuron apoptotic process intermediate filament polymerization neuron projection morphogenesis positive regulation of axonogenesis neuromuscular process controlling balance neuron projection development cellular response to oxidative stress response to cocaine cellular response to estradiol stimulus cellular response to hydroperoxide
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