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Invitrogen

ERK2 Monoclonal Antibody (4C11)

View all (72) ERK2 antibodies

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Product Details

MA5-15304

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

4C11

Immunogen

Purified recombinant fragment of human ERK2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980249

Product Specific Information

MA5-15304 targets ERK2 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples.

The MA5-15304 immunogen is purified recombinant fragment of human ERK2 expressed in E. Coli.

MA5-15304 detects ERK2 which has a predicted molecular weight of approximately 41kDa.

Target Information

MAPK1 (ERK2) is a serine/threonine kinase that acts as an important activator of p90 RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ERK-2; Erk2; cancer susceptibility protein; ERT1; extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; mitogen-activated protein kinase 2; p42-MAPK; protein tyrosine kinase ERK2; unnamed protein product

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Gene Aliases: 9030612K14Rik; ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2

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UniProt ID: (Human) P28482, (Mouse) P63085

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Entrez Gene ID: (Human) 5594, (Mouse) 26413

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Function(s)
phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding RNA polymerase II carboxy-terminal domain kinase activity kinase activity phosphatase binding identical protein binding protein serine kinase activity double-stranded DNA binding protein kinase binding mitogen-activated protein kinase kinase kinase binding
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter protein phosphorylation apoptotic process chemotaxis signal transduction cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway chemical synaptic transmission learning or memory insulin receptor signaling pathway positive regulation of macrophage chemotaxis positive regulation of peptidyl-threonine phosphorylation Schwann cell development positive regulation of telomere maintenance regulation of stress-activated MAPK cascade cellular response to amino acid starvation response to nicotine intracellular signal transduction ERBB signaling pathway ERBB2-ERBB3 signaling pathway myelination positive regulation of skeletal muscle tissue regeneration positive regulation of cholesterol biosynthetic process positive regulation of smoothened signaling pathway insulin-like growth factor receptor signaling pathway stress-activated MAPK cascade regulation of cytoskeleton organization interleukin-34-mediated signaling pathway chemokine-mediated signaling pathway ERK1 and ERK2 cascade response to epidermal growth factor caveolin-mediated endocytosis regulation of Golgi inheritance positive regulation of macrophage proliferation positive regulation of neuroinflammatory response regulation of early endosome to late endosome transport placenta development cellular response to DNA damage stimulus heart development response to toxic substance organ morphogenesis neural crest cell development diadenosine tetraphosphate biosynthetic process peptidyl-serine phosphorylation sensory perception of pain cytosine metabolic process regulation of ossification thyroid gland development lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide mammary gland epithelial cell proliferation positive regulation of protein import into nucleus outer ear morphogenesis response to exogenous dsRNA response to estrogen negative regulation of cell differentiation positive regulation of translation positive regulation of transcription, DNA-templated decidualization thymus development T cell receptor signaling pathway B cell receptor signaling pathway regulation of intracellular pH Bergmann glial cell differentiation positive regulation of cardiac muscle cell proliferation long-term synaptic potentiation face development lung morphogenesis trachea formation labyrinthine layer blood vessel development cardiac neural crest cell development involved in heart development cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to lipid cellular response to toxic substance
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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