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Invitrogen

SRC Monoclonal Antibody (5D10C4)

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SRC Monoclonal Antibody (5D10C4)

Product Details

MA5-15412

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

5D10C4

Immunogen

Purified recombinant fragment of SRC (aa10-193) expressed in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10982227

Product Specific Information

MA5-15412 targets SRC in indirect ELISA, WB applications and shows reactivity with Human samples.

The MA5-15412 immunogen is purified recombinant fragment of SRC (aa10-193) expressed in E. Coli.
.

Target Information

SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. SRC is involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.10.2; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; pp60src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; RP5-823N20.1; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; unnamed protein product; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

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Gene Aliases: ASV; c-SRC; p60-Src; SRC1; THC6

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UniProt ID: (Human) P12931

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Entrez Gene ID: (Human) 6714

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Function(s)
protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding integrin binding protein binding ATP binding phospholipase activator activity kinase activity enzyme binding protein domain specific binding heme binding protein tyrosine kinase activator activity receptor activator activity ionotropic glutamate receptor binding SH2 domain binding phospholipase binding ion channel binding cadherin binding ephrin receptor binding ATPase binding phosphoprotein binding BMP receptor binding connexin binding scaffold protein binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter stimulatory C-type lectin receptor signaling pathway negative regulation of inflammatory response to antigenic stimulus cell adhesion signal transduction signal complex assembly epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway lactation regulation of epithelial cell migration positive regulation of epithelial cell migration macroautophagy peptidyl-tyrosine phosphorylation regulation of cell-cell adhesion cell differentiation platelet activation osteoclast differentiation T cell costimulation negative regulation of protein complex assembly protein destabilization negative regulation of telomere maintenance positive regulation of integrin activation regulation of toll-like receptor 3 signaling pathway cellular response to reactive oxygen species positive regulation of Rac protein signal transduction positive regulation of dephosphorylation negative regulation of hippo signaling intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway angiotensin-activated signaling pathway vasodilation negative regulation of apoptotic process regulation of vascular permeability stress fiber assembly regulation of bone resorption bone resorption positive regulation of Notch signaling pathway positive regulation of glycolytic process viral entry into host cell vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway focal adhesion assembly progesterone receptor signaling pathway leukocyte migration positive regulation of small GTPase mediated signal transduction negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization intestinal epithelial cell development interleukin-6-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to peptide hormone stimulus cellular response to progesterone stimulus regulation of heart rate by cardiac conduction negative regulation of neutrophil activation positive regulation of TORC1 signaling positive regulation of lamellipodium morphogenesis regulation of early endosome to late endosome transport negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway regulation of caveolin-mediated endocytosis
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