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Invitrogen
LIN28A Monoclonal Antibody (6D1F9)
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Product Details
MA5-15453
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6D1F9
Immunogen
Purified recombinant fragment of LIN28 (aa93-209) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites, pH 7.4
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15453 targets LIN28 in indirect ELISA, IF, ICC, and WB applications and shows reactivity with human samples.
The MA5-15453 immunogen is purified recombinant fragment of LIN28 (aa93-209) expressed in E. Coli.
MA5-15453 detects LIN28 which has a predicted molecular weight of approximately 23kDa.
Target Information
Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ12457; Lin-28A; Protein lin-28 homolog A; RNA-binding protein LIN-28; unnamed protein product; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
Gene Aliases: CSDD1; LIN-28; lin-28A; LIN28; LIN28A; ZCCHC1
UniProt ID: (Human) Q9H9Z2
Entrez Gene ID: (Human) 79727
germ cell development
miRNA metabolic process
miRNA catabolic process
posttranscriptional regulation of gene expression
negative regulation of translation
stem cell population maintenance
gene silencing by RNA
pre-miRNA processing
RNA 3'-end processing
positive regulation of TOR signaling
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of translation
stem cell differentiation
positive regulation of protein kinase B signaling
regulation of gene silencing by miRNA
cellular response to glucose stimulus
positive regulation of cell proliferation involved in kidney development
negative regulation of pre-miRNA processing
positive regulation of cytoplasmic translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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