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Invitrogen

ISL1 Monoclonal Antibody (1B1)

View all (37) ISL1 antibodies

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Product Details

MA5-15516

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1B1

Immunogen

Purified recombinant fragment of human ISL1 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10982886

Product Specific Information

MA5-15516 targets ISL1 in indirect ELISA, IF and WB applications and shows reactivity with Human samples.

The MA5-15516 immunogen is purified recombinant fragment of human ISL1 expressed in E. Coli.

MA5-15516 detects ISL1 which has a predicted molecular weight of approximately 39kDa.

Target Information

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeobox; Insulin gene enhancer protein ISL-1; insulin related protein; Islet 1; Islet-1; Lim-homeodomain protein Islet1; unnamed protein product

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Gene Aliases: Isl-1; ISL1; ISLET1

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UniProt ID: (Human) P61371, (Mouse) P61372

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Entrez Gene ID: (Human) 3670, (Mouse) 16392

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding protein binding ligand-dependent nuclear receptor binding LIM domain binding estrogen receptor binding bHLH transcription factor binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity enhancer sequence-specific DNA binding zinc ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neural crest cell migration heart morphogenesis secondary heart field specification outflow tract septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis regulation of secondary heart field cardioblast proliferation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development heart development positive regulation of cell proliferation regulation of gene expression positive regulation of vascular endothelial growth factor production spinal cord motor neuron cell fate specification spinal cord motor neuron differentiation visceral motor neuron differentiation trigeminal nerve development pituitary gland development neuron differentiation pancreas development retinal ganglion cell axon guidance positive regulation of insulin secretion positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production negative regulation of intracellular estrogen receptor signaling pathway positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of DNA binding negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter neuron fate commitment neuron fate specification mesenchymal cell differentiation sensory system development peripheral nervous system neuron development peripheral nervous system neuron axonogenesis negative regulation of inflammatory response ventricular cardiac muscle tissue morphogenesis pharyngeal system development cardiac muscle cell myoblast differentiation innervation atrial septum morphogenesis cardiac cell fate determination positive regulation of granulocyte colony-stimulating factor production negative regulation of protein homodimerization activity negative regulation of canonical Wnt signaling pathway positive regulation of macrophage colony-stimulating factor production axonogenesis cell proliferation positive regulation of epithelial to mesenchymal transition cell differentiation axon regeneration negative regulation of protein complex assembly positive regulation of cell differentiation positive regulation of smoothened signaling pathway stem cell differentiation negative regulation of epithelial cell proliferation canonical Wnt signaling pathway sinoatrial node cell development cellular response to glucocorticoid stimulus cellular response to transforming growth factor beta stimulus negative regulation of mesenchymal cell proliferation regulation of heart rate by cardiac conduction positive regulation of calcium ion import positive regulation of type B pancreatic cell apoptotic process
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