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Invitrogen
FGFR1 Monoclonal Antibody (3D4F7)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15530
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3D4F7
Immunogen
Purified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15530 targets FGFR1 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15530 immunogen is purified recombinant extracellular fragment of human FGFR1 (aa33-423) fused with hIgGFc tag expressed in HEK293 cells.
MA5-15530 detects FGFR1 which has a predicted molecular weight of approximately 92kDa.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.10.1; basic fibroblast growth factor receptor 1; CD331 antigen; FGF Receptor; FGF receptor-1 precursor; FGFR; fgfr 1; FGFR1/PLAG1 fusion; fibroblast growth factor receptor (FGFr) transmembrane form; fibroblast growth factor receptor FGFR-1 secreted form; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; proto-oncogene c-Fgr; unnamed protein product
Gene Aliases: bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD
UniProt ID: (Human) P11362
Entrez Gene ID: (Human) 2260
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
protein binding
ATP binding
heparin binding
fibroblast growth factor binding
identical protein binding
protein homodimerization activity
receptor-receptor interaction
MAPK cascade
skeletal system development
neuron migration
epithelial to mesenchymal transition
protein phosphorylation
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of phospholipase activity
cell migration
peptidyl-tyrosine phosphorylation
chordate embryonic development
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
cellular response to fibroblast growth factor stimulus
regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of neuron differentiation
protein autophosphorylation
phosphatidylinositol-mediated signaling
generation of neurons
skeletal system morphogenesis
positive regulation of protein kinase B signaling
positive regulation of vascular endothelial cell proliferation
positive regulation of endothelial cell chemotaxis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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