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Invitrogen
Nkx2.5 Monoclonal Antibody (2E1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15551
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2E1
Immunogen
Purified recombinant fragment of human NKX2.5 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15551 targets NKX2.5 in indirect ELISA and WB applications, this antibody also shows reactivity with Human samples.
The MA5-15551 immunogen is purified recombinant fragment of human NKX2.5 expressed in E. Coli.
MA5-15551 detects NKX2.5 which has a predicted molecular weight of approximately 35kDa
Target Information
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac-specific homeobox 1; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; homeobox protein CSX; homeobox protein NK-2 homolog E; homeobox protein NKX 2-5; NK2 transcription factor related locus 5 (Drosophila) isoform NKX2-5_1; NK2 transcription factor related locus 5 (Drosophila) isoform NKX2-5_2; NK2 transcription factor related, locus 5; NKX 2-5; Nkx-2.5; Nkx-25; tinman homolog; tinman paralog; unnamed protein product
Gene Aliases: CHNG5; CSX; CSX1; HLHS2; NKX2.5; NKX2E; NKX4-1; VSD3
UniProt ID: (Human) P52952
Entrez Gene ID: (Human) 1482
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
heart looping
heart morphogenesis
outflow tract septum morphogenesis
cardiac conduction system development
atrioventricular node development
bundle of His development
aortic valve morphogenesis
right ventricular cardiac muscle tissue morphogenesis
atrial cardiac muscle tissue development
septum secundum development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
adult heart development
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
positive regulation of sodium ion transport
negative regulation of myotube differentiation
hemopoiesis
cell differentiation
thyroid gland development
embryonic heart tube development
negative regulation of apoptotic process
positive regulation of neuron differentiation
positive regulation of heart contraction
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
cardiac muscle cell development
atrial cardiac muscle cell development
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
pharyngeal system development
positive regulation of transcription initiation from RNA polymerase II promoter
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of canonical Wnt signaling pathway
regulation of cardiac conduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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