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Invitrogen
NGFR Monoclonal Antibody (2F1C2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15574
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F1C2
Immunogen
Purified recombinant fragment of human NGFR expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15574 targets NGFR in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15574 immunogen is purified recombinant fragment of human NGFR expressed in E. Coli.
MA5-15574 detects NGFR which has a predicted molecular weight of approximately 45kDa.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD271 antigen; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; low-affinity nerve growth factor receptor p75NGFR; low-affinity nerve growth factor receptor p75NGR; NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; unnamed protein product
Gene Aliases: CD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16
UniProt ID: (Human) P08138
Entrez Gene ID: (Human) 4804
cellular glucose homeostasis
intracellular protein transport
signal transduction
Rho protein signal transduction
circadian rhythm
negative regulation of cell migration
circadian regulation of gene expression
dorsal aorta development
regulation of cell proliferation
glucose homeostasis
positive regulation of apoptotic process
neuron apoptotic process
extrinsic apoptotic signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of protein localization to nucleus
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
cellular response to beta-amyloid
positive regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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