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Invitrogen
AKT2 Monoclonal Antibody (1B6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15593
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1B6
Immunogen
Purified recombinant fragment of human AKT2 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15593 targets AKT2 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human, Non-human primate, and Rat samples.
The MA5-15593 immunogen is purified recombinant fragment of human AKT2 expressed in E. Coli.
MA5-15593 detects AKT2 which has a predicted molecular weight of approximately 60kDa.
Target Information
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Akt2; AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; protein kinase Akt-2; protein kinase B beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-PK-beta; thymoma viral proto-oncogene 2; unnamed protein product; v-akt murine thymoma viral oncogene homolog 2
Gene Aliases: HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA
UniProt ID: (Human) P31751, (Rat) P47197
Entrez Gene ID: (Human) 208, (Rat) 25233
signal transduction
insulin receptor signaling pathway
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
regulation of cell migration
positive regulation of cell migration
positive regulation of fatty acid beta-oxidation
cellular response to insulin stimulus
intracellular signal transduction
protein modification process
negative regulation of apoptotic process
positive regulation of blood vessel endothelial cell migration
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
protein stabilization
regulation of cell cycle
mammary gland epithelial cell differentiation
positive regulation of protein targeting to membrane
positive regulation of cap-dependent translational initiation
negative regulation of PERK-mediated unfolded protein response
positive regulation of cell motility
response to hypoxia
positive regulation of protein phosphorylation
glucose metabolic process
protein phosphorylation
positive regulation of signal transduction
positive regulation of gene expression
positive regulation of sodium ion transport
response to muscle activity
response to nutrient levels
peripheral nervous system myelin maintenance
response to insulin
cellular response to hormone stimulus
negative regulation of RNA splicing
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of positive chemotaxis
cellular response to high light intensity
protein localization to plasma membrane
activation of GTPase activity
retinal rod cell apoptotic process
positive regulation of adipose tissue development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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