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Invitrogen
SLUG Monoclonal Antibody (2H5)
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Product Details
MA5-15628
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2H5
Immunogen
Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15628 targets SNAI2 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15628 immunogen is purified recombinant fragment of human SNAI2 expressed in E. Coli.
MA5-15628 detects SNAI2 which has a predicted molecular weight of approximately 30kDa.
Target Information
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; snail family zinc finger 2; snail homolog 2; unnamed protein product; Zinc finger protein SNAI2; zinc-finger protein
Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D
UniProt ID: (Human) O43623
Entrez Gene ID: (Human) 6591
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
E-box binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
epithelial to mesenchymal transition
aortic valve morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
cell migration involved in endocardial cushion formation
chromatin organization
regulation of transcription, DNA-templated
substrate-dependent cell migration
negative regulation of cell adhesion involved in substrate-bound cell migration
Notch signaling pathway
sensory perception of sound
response to radiation
epithelial cell migration
negative regulation of keratinocyte proliferation
negative regulation of vitamin D biosynthetic process
neural crest cell development
positive regulation of cell migration
negative regulation of chondrocyte differentiation
regulation of chemokine production
myeloid cell apoptotic process
negative regulation of myeloid cell apoptotic process
negative regulation of cell adhesion mediated by integrin
desmosome disassembly
pigmentation
negative regulation of DNA damage response, signal transduction by p53 class mediator
endothelial cell migration
positive regulation of fat cell differentiation
regulation of osteoblast differentiation
mesenchymal cell differentiation
white fat cell differentiation
palate development
epithelium development
cartilage morphogenesis
regulation of branching involved in salivary gland morphogenesis
negative regulation of vitamin D receptor signaling pathway
cellular response to epidermal growth factor stimulus
hematopoietic stem cell proliferation
cellular response to ionizing radiation
negative regulation of canonical Wnt signaling pathway
negative regulation of hematopoietic stem cell proliferation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of bicellular tight junction assembly
negative regulation of anoikis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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