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Invitrogen
IHOG Monoclonal Antibody (3G8)
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Product Details
MA5-15648
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3G8
Immunogen
Purified recombinant fragment of human IHOG expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15648 targets IHOG in indirect ELISA, WB applications and shows reactivity with Drosophila samples.
The MA5-15648 immunogen is purified recombinant fragment of human IHOG expressed in E. Coli.
MA5-15648 detects IHOG which has a predicted molecular weight of approximately 98kDa.
Target Information
The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG9211-PA; Dmel ihog; GH03927p; ihog-PA; Interference hedgehog
Gene Aliases: CG9211; CT26314; Dmel\CG9211; Dmel_CG9211; IHOG
UniProt ID: (Fruit fly) Q9VM64
Entrez Gene ID: (Fruit fly) 33972
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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