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Invitrogen
KLF4 Monoclonal Antibody (1E5)
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Product Details
MA5-15672
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E5
Immunogen
Immunogen is purified recombinant fragment of human KLF4 (Amino Acid: 2-470) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15672 targets KLF4 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15672 immunogen is purified recombinant fragment of human KLF4 (Amino Acid: 2-470) expressed in E. Coli.
MA5-15672 detects KLF4 which has a predicted molecular weight of approximately 55kDa.
Target Information
Kruppel like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. It is also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF) and belongs to a family of conserved Kruppel-like factor family of DNA binding zinc finger transcription factors. KLF4 exerts its functional relevance across varied cellular pathways. As one of the four Yamanaka factors, it plays a key role in reprogramming differentiated cells into pluripotent stem cells. Most studies have focused on its specific role in endothelial cell signaling, adipogenesis, differentiation, embryogenesis and cell cycle control. Localization plays an important role in the biological significance of this protein wherein nuclear localization is associated with its function as an oncogene and cytosolic localization with tumor suppression specific effect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 4; Kruppel like factor 4; Kruppel-like factor 4 (gut); Kruppel-like zinc finger protein; RP11-150J11.1; transcription factor; unnamed protein product
Gene Aliases: EZF; GKLF; KLF4
UniProt ID: (Human) O43474
Entrez Gene ID: (Human) 9314
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding transcription factor recruiting
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
zinc ion binding
chromatin DNA binding
phosphatidylinositol 3-kinase regulator activity
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
lncRNA binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
defense response to tumor cell
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mesodermal cell fate determination
negative regulation of cell proliferation
epidermis development
epidermal cell differentiation
gene expression
positive regulation of gene expression
negative regulation of gene expression
negative regulation of muscle hyperplasia
negative regulation of angiogenesis
stem cell population maintenance
negative regulation of cell migration
epithelial cell differentiation
post-embryonic camera-type eye development
positive regulation of telomere maintenance
response to retinoic acid
negative regulation of interleukin-8 production
negative regulation of heterotypic cell-cell adhesion
somatic stem cell population maintenance
post-embryonic hemopoiesis
regulation of cell proliferation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hemoglobin biosynthetic process
negative regulation of smooth muscle cell proliferation
regulation of axon regeneration
epidermis morphogenesis
negative regulation of inflammatory response
positive regulation of protein metabolic process
negative regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of response to cytokine stimulus
establishment of skin barrier
cellular response to hydrogen peroxide
negative regulation of ERK1 and ERK2 cascade
cellular response to retinoic acid
cellular response to growth factor stimulus
cellular response to laminar fluid shear stress
negative regulation of cell migration involved in sprouting angiogenesis
regulation of blastocyst development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of sprouting angiogenesis
negative regulation of leukocyte adhesion to arterial endothelial cell
cellular response to leukemia inhibitory factor
cellular response to endothelin
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of chemokine (C-X-C motif) ligand 2 production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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