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Invitrogen
IKK alpha Monoclonal Antibody (3G12H9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15696
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3G12H9
Immunogen
Purified recombinant fragment of human CHUK expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15696 targets CHUK in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15696 immunogen is purified recombinant fragment of human CHUK expressed in E. Coli.
MA5-15696 detects CHUK which has a predicted molecular weight of approximately 85kDa.
Target Information
CHUK (IKK alpha) is a serine/threonine kinase involved in signal transduction and cellular communication. It belongs to the cytokine activated protein complex that is an inhibitor of the NF-kappa B complex. IKK alpha along with IKK beta and a regulatory protein NEMO (IKK gamma) phosphorylates IkB proteins which targets the later for ubiquitin mediated degradation. It is involved with several cellular processes with extensive studies on its role in inflammation and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; FLJ40509; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; ikappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IKBKB; IKK-a kinase; IKK-B; IKK-beta; IKK2; IKKB; kinase beta; MGC131801; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; protein kinase; transcription factor 16; unnamed protein product
Gene Aliases: BPS2; Chuk1; Fbx24; Fbxo24; IKBKA; IKK alpha; IKK-1; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
UniProt ID: (Human) O15111
Entrez Gene ID: (Human) 1147, (Mouse) 12675
morphogenesis of an epithelial sheet
regulation of transcription from RNA polymerase II promoter
integrin-mediated signaling pathway
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
lactation
osteoclast differentiation
positive regulation of interferon-alpha production
tumor necrosis factor-mediated signaling pathway
mammary gland epithelial cell proliferation
toll-like receptor 4 signaling pathway
response to muscle stretch
NIK/NF-kappaB signaling
odontogenesis of dentin-containing tooth
positive regulation of I-kappaB kinase/NF-kappaB signaling
skin development
positive regulation of transcription from RNA polymerase II promoter
striated muscle cell differentiation
defense response to virus
mammary gland alveolus development
response to cholecystokinin
cellular response to tumor necrosis factor
cellular response to virus
pattern recognition receptor signaling pathway
skeletal muscle contraction
inflammatory response
immune response
response to xenobiotic stimulus
response to virus
response to toxic substance
anatomical structure morphogenesis
response to acetate
response to hydroperoxide
response to amino acid
innate immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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