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Invitrogen
KLHL22 Monoclonal Antibody (7B10)
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Product Details
MA5-15699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7B10
Immunogen
Purified recombinant fragment of human KLHL22 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15699 targets KLHL22 in indirect ELISA, IF and WB applications and shows reactivity with Human samples.
The MA5-15699 immunogen is purified recombinant fragment of human KLHL22 expressed in E. Coli.
MA5-15699 detects KLHL22 which has a predicted molecular weight of approximately 72kDa.
Target Information
KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophila kelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Em:AC005500.4; kelch-like 22; Kelch-like protein 22; unnamed protein product
Gene Aliases: 2610318I18Rik; KELCHL; KLHL22
UniProt ID: (Human) Q53GT1, (Mouse) Q99JN2
Entrez Gene ID: (Human) 84861, (Mouse) 224023
mitotic sister chromatid segregation
protein monoubiquitination
cell cycle
mitotic nuclear division
mitotic spindle assembly checkpoint
protein ubiquitination
cell division
negative regulation of T cell mediated immune response to tumor cell
positive regulation of T cell mediated immune response to tumor cell
ubiquitin-dependent protein catabolic process
negative regulation of autophagy
positive regulation of cell growth
cellular response to nutrient levels
negative regulation of type I interferon production
positive regulation of type I interferon production
cellular response to amino acid starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of T cell activation
positive regulation of T cell activation
cellular response to amino acid stimulus
cellular response to leucine
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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