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Invitrogen

p73 delta Monoclonal Antibody (38C674.2)

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p73 delta Monoclonal Antibody (38C674.2)

Product Details

MA5-16183

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

1:20-1:1,000
-

Immunocytochemistry (ICC/IF)

1:20-1:1,000
-

ChIP assay (ChIP)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

38C674.2

Immunogen

Peptide corresponding to a portion of amino acid residues 1-50 of human dNp73.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2537702

Target Information

p73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1) It was found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; transformation related protein 73; unnamed protein product

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Gene Aliases: CILD47; deltaNp73; P73; TAp73; Tp73; Trp73

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UniProt ID: (Human) O15350, (Mouse) Q9JJP2

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Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding identical protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding MDM2/MDM4 family protein binding DNA-binding transcription factor binding promoter-specific chromatin binding sequence-specific DNA binding
Process(es)
kidney development regulation of transcription, DNA-templated apoptotic process cellular response to DNA damage stimulus regulation of mitotic cell cycle negative regulation of cell proliferation response to xenobiotic stimulus regulation of gene expression intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process positive regulation of MAPK cascade negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of oligodendrocyte differentiation protein tetramerization regulation of cell cycle negative regulation of cardiac muscle cell proliferation positive regulation of lung ciliated cell differentiation release of cytochrome c from mitochondria inflammatory response post-embryonic development hippocampus development forebrain development cerebrospinal fluid secretion negative regulation of JUN kinase activity regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of cell size cell development digestive tract morphogenesis neuron development apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway mismatch repair intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of cell differentiation
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