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Invitrogen

HLA-DR/DQ Monoclonal Antibody (49.1), FITC

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Product Details

MA5-16518

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1:10
-
Product Specifications

Species Reactivity

Bovine, Goat, Human, Sheep

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

49.1

Immunogen

The details of the immunogen for this antibody are not currently available.

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS with 1% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538029

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Target Information

The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infections. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ, each composed of an alpha and beta chain. The polymorphic epitope on ovine MHC class II DQ and DR molecules is constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Bioinformatics

Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DRB52; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-D; HLA-DQ; HLA-DQ-beta-1 cell surface glycoprotein; HLA-DQB1; HLA-DR; hla-dr antigen beta chain; HLA-DR-beta chain; HLA-DRB1; human leucocyte antigen; human leucocyte antigen DRB1; lymphocyte antigen DRB1; MHC Class 2; MHC class II; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II DQ-beta protein precursor; MHC class II DQ3.1ER protein; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR4 protein; MHC DQ beta protein precursor; MHC DQ-beta chain; MHC DQw1-beta surface glycoprotein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-2 chain; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-D; MHC HLA-DC-beta chain precursor; MHC HLA-DQ-beta cell surface glycoprotein; MHC HLA-DQ-beta chain precursor old gene name 'HLA-DQB'; MHC HLA-DQ-beta precursor; MHC HLA-DQB1-beta protein; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DRQ-beta chain; MHC HLA-DRw10-beta-2 protein precursor; MHC II HLA; unnamed protein product

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Gene Aliases: CELIAC1; DRB1; HLA-DQB; HLA-DR1B; HLA-DRB; IDDM1; SS1

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UniProt ID: (Human) P01920, (Human) P01911

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Entrez Gene ID: (Human) 3119, (Human) 3123

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Function(s)
protein binding MHC class II protein complex binding MHC class II receptor activity peptide antigen binding structural constituent of cytoskeleton polysaccharide binding T cell receptor binding CD4 receptor binding
Process(es)
peptide antigen assembly with MHC class II protein complex immune response humoral immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of immune response T cell receptor signaling pathway positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity inflammatory response to antigenic stimulus myeloid dendritic cell antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II positive regulation of T cell mediated immune response to tumor cell negative regulation of inflammatory response to antigenic stimulus cytoskeleton organization signal transduction epidermis development detection of bacterium macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation positive regulation of memory T cell differentiation regulation of T-helper cell differentiation positive regulation of monocyte differentiation protein tetramerization positive regulation of CD4-positive, alpha-beta T cell activation
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