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Invitrogen
P-Glycoprotein Monoclonal Antibody (UIC2)
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Product Details
MA5-16959
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
UIC2
Immunogen
Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody does not react with mouse or rat.
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is human kidney. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Human CD243, clone UIC2 recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), a multi pass transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, containing two ABC transporter type 1 domains and two ABC transporter domains.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette, sub-family B (MDR/TAP), member 1; colchicin sensitivity; doxorubicin resistance; MDR1; P-glycoprotein; multidrug resistance protein 1; multidrug-resistance; P-glycoprotein; P-glycoprotein 1; phospholipid transporter ABCB1; unnamed protein product; uORF
Gene Aliases: ABC20; CD243; CLCS; ENPAT; GP170; MDR1; p-170; P-GP; PGY1
UniProt ID: (Human) P08183
Entrez Gene ID: (Human) 5243
protein binding
ATP binding
xenobiotic-transporting ATPase activity
efflux transmembrane transporter activity
ATPase activity
transmembrane transporter activity
ubiquitin protein ligase binding
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
carboxylic acid transmembrane transporter activity
phosphatidylcholine-translocating ATPase activity
phosphatidylethanolamine flippase activity
ceramide floppase activity
ATPase-coupled intramembrane lipid transporter activity
floppase activity
phosphatidylethanolamine floppase activity
ABC-type transporter activity
G2/M transition of mitotic cell cycle
xenobiotic metabolic process
response to xenobiotic stimulus
phospholipid translocation
terpenoid transport
transmembrane transport
transepithelial transport
stem cell proliferation
ceramide translocation
export across plasma membrane
transport across blood-brain barrier
carboxylic acid transmembrane transport
drug transmembrane export
drug transport across blood-brain barrier
regulation of chloride transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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