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Invitrogen
TAOK2 Monoclonal Antibody (2F4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-20685
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2F4
Immunogen
TAOK2 (AAH51798, 831 a.a. ~ 930 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide Sequence: ELQCRQYKRK MLLARHSLDQ DLLREDLNKK QTQKDLECAL LLRQHEATRE LELRQLQAVQ RTRAELTRLQ HQTELGNQLE YNKRREQELR QKHAAQVRQQ
Target Information
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hKFC-C; kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; prostate-derived sterile 20-like kinase 1; protein kinase homolog; PSK-1; tao; thousand and one amino acid protein kinase 2; unnamed protein product
Gene Aliases: MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2; Tao2beta
UniProt ID: (Human) Q9UL54
Entrez Gene ID: (Human) 9344
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
mitogen-activated protein kinase kinase binding
neuropilin binding
protein serine/threonine kinase activator activity
tau protein binding
tau-protein kinase activity
protein serine kinase activity
regulation of cell growth
protein targeting to membrane
apoptotic process
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
axonogenesis
regulation of cell shape
cell migration
actin cytoskeleton organization
positive regulation of stress-activated MAPK cascade
regulation of actin cytoskeleton organization
positive regulation of MAPK cascade
positive regulation of JNK cascade
focal adhesion assembly
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
stress-activated MAPK cascade
basal dendrite morphogenesis
basal dendrite arborization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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