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Invitrogen
CRSP130 Monoclonal Antibody (4H6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-20718
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4H6
Immunogen
MED23 (NP_004821, 531 a.a. ~ 630 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2-1.0 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide Sequence: LTVHAKMSLI HSIATRVIKL AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL
Target Information
CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits. Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS. CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins. CRSP subunits also associate with larger multimeric co-activator complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; activator-recruited cofactor 130 kDa component; cofactor required for Sp1 transcriptional activation subunit 3; subunit of SRB/mediator complex; unnamed protein product; vitamin D3 receptor interacting protein
Gene Aliases: ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR-2; SUR2
UniProt ID: (Human) Q9ULK4
Entrez Gene ID: (Human) 9439
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of transcription initiation from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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