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Invitrogen
PARL Monoclonal Antibody (4F4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-22148
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
4F4
Immunogen
PARL (NP_061092.3, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2-1.0 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide Sequence: AWRGWAQRGW GCGQAWGASV GGRSCEELTA VLTPPQLLGR RFNFFIQQKC GFRKAPRKVE PRRSDPGTSG EAYKRSALIP PVEETVFYPS PYPIRSLIK
Target Information
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitochondrial intramembrane-cleaving protease PARL; presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1
Gene Aliases: PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
UniProt ID: (Human) Q9H300
Entrez Gene ID: (Human) 55486
proteolysis
mitochondrial fusion
regulation of mitochondrion organization
protein processing
regulation of proteolysis
membrane protein proteolysis
negative regulation of release of cytochrome c from mitochondria
regulation of mitophagy
regulation of protein localization to mitochondrion
regulation of reactive oxygen species metabolic process
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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