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Invitrogen
VPS18 Monoclonal Antibody (4E9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-22391
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
4E9
Immunogen
VPS18 (NP_065908, 3 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide Sequence: SILDEYENSL SRSAVLQPGC PSVGIPHSGY VNAQLEKEVP IFTKQRIDFT PSERITSLVV SSNQLCMSLG KDTLLRIDLG KANEPNHVEL GRKDDAKV
Target Information
VPS18 is a vesicle mediated protein that plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hVPS18; vacuolar protein sorting 18 homolog; vacuolar protein sorting protein 18; VPS18, CORVET/HOPS core subunit
Gene Aliases: PEP3
UniProt ID: (Human) Q9P253
Entrez Gene ID: (Human) 57617
intracellular protein transport
endosome organization
lysosome organization
endosome to lysosome transport
vesicle-mediated transport
protein ubiquitination
negative regulation of intracellular estrogen receptor signaling pathway
endosomal vesicle fusion
regulation of SNARE complex assembly
organelle fusion
autophagosome-lysosome fusion
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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