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Invitrogen
MCP-5 Monoclonal Antibody (63205)
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FIGURE: 1 / 1
MCP-5 Antibody (MA5-23841) in Neu
Neutralization of MCP-5 in BaF3 mouse pro‚B cell line transfected with human CCR2A. Samples were incubated in MCP-5 monoclonal antibody (Product # MA5-23841). Recombinant Mouse CCL12/MCP‚5 chemoattracts the BaF3 mouse pro‚B cell line transfected with human CCR2A in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse CCL12/MCP‚5 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-23841
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
63205
Immunogen
E. coli-derived recombinant mouse CCL12/MCP-5 Gly23-Gly104
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chemokine (C-C motif) ligand 12; MCP-1-related chemokine; MCP-5; monocyte chemoattractant protein 5; monocyte chemotactic protein 5; small-inducible cytokine A12; unnamed protein product
Gene Aliases: MCP-5; Scya12
UniProt ID: (Mouse) Q62401
Entrez Gene ID: (Mouse) 20293
angiogenesis
monocyte chemotaxis
positive regulation of leukocyte migration
inflammatory response
immune response
positive regulation of cell migration
eosinophil chemotaxis
antimicrobial humoral immune response mediated by antimicrobial peptide
chemokine-mediated signaling pathway
negative regulation of leukocyte proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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