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Invitrogen
CD300b Monoclonal Antibody (339003)
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Product Details
MA5-24069
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
339003
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CD300b/LMIR5 Ile18-Tyr157
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, 100% cross-reactivity with recombinant human (rh) LMIR5 is observed and no cross-reactivity with recombinant mouse (rm) LMIR3, rmLMIR4, rhLMIR1, rhLMIR2, or rhLMIR6 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CD300 molecule-like family member b (CD300LB), also known as CLM-7, is a gene located on chromosome 17q25.1, encoding an immunoreceptor that belongs to the CD300 family of molecules. CD300LB is primarily expressed on the surface of myeloid cells, including dendritic cells and macrophages, where it plays an essential role in modulating immune responses. The receptor is involved in the regulation of cell activation and inflammatory responses through its interactions with phosphatidylserine and other lipid ligands, which can lead to either activation or inhibition of immune cell functions. CD300LB influences processes like antigen presentation, phagocytosis, and cytokine production, thereby impacting innate immune responses and the maintenance of immune homeostasis. Its expression and activity are of particular interest in contexts like autoimmunity, infection, and cancer, where it may contribute to disease progression and serve as a potential therapeutic target in modulating immune functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD300 antigen like family member B; clm-7; CMRF-35-like molecule-7; immune activating receptor; immune receptor expressed on myeloid cells 3; IREM-3; leukocyte mono-Ig-like receptor 5; unnamed protein product
Gene Aliases: CLM-7; Clm7; Gm253; LMIR5
UniProt ID: (Mouse) Q3U497
Entrez Gene ID: (Mouse) 217304
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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