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Invitrogen
DCC Monoclonal Antibody (531505)
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Product Details
MA5-24233
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
531505
Immunogen
E. coli-derived recombinant human DCC Ser1323-Phe1447
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: colorectal cancer suppressor; colorectal tumor suppressor (put.); putative; deleted in colorectal carcinoma; immunoglobulin superfamily DCC subclass member 1; putative colorectal tumor suppressor; tumor suppressor protein DCC; unnamed protein product
Gene Aliases: CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146
Entrez Gene ID: (Human) 1630
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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